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PF-03049423 B
CAS No. 954138-07-9
PF-03049423 B ( —— )
产品货号. M37613 CAS No. 954138-07-9
PF-03049423 (Compound PF-5) free base 是一种有效的，高选择性的 phosphodiesterase-5A 抑制剂，对大鼠和人血小板酶的 IC50 约为 0.2 nM。PF-03049423 free base 可用于急性缺血性中风的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1021 | 有现货 |
|
| 5MG | ￥1437 | 有现货 |
|
| 10MG | ￥2204 | 有现货 |
|
| 25MG | ￥3511 | 有现货 |
|
| 50MG | ￥4974 | 有现货 |
|
| 100MG | ￥6518 | 有现货 |
|
| 200MG | ￥8798 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PF-03049423 B
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PF-03049423 (Compound PF-5) free base 是一种有效的，高选择性的 phosphodiesterase-5A 抑制剂，对大鼠和人血小板酶的 IC50 约为 0.2 nM。PF-03049423 free base 可用于急性缺血性中风的研究。
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产品描述PF-03049423 (Compound PF-5) free base is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 free base can be used for the research of acute ischaemic stroke.
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体外实验——
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体内实验PF-03049423 (Compound PF-5) (1-10 mg/kg; s.c.; b.i.d. for 7 days) promotes functional recovery in a rat model of severe stroke induced by permanent middle cerebral artery occlusion.PF-03049423 (1.0 mg/kg b.i.d. or 0.6 mg/kg q.d. for 7 days) improves poststroke sensory–motor behavioral outcome even when the treatment is initiated 24-72 hours after occlusion.Animal Model:Male Sprague-Dawley rats, middle cerebral artery occlusion (MCA-o) model Dosage:0.1, 1, or 10 mg/kg Administration:Subcutaneous injection, b.i.d. for 7 daysResult:Improved functional recovery at 1 mg/kg and 10 mg/kg.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number954138-07-9
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分子量468.55
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分子式C24H32N6O4
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纯度>98% (HPLC)
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溶解度——
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SMILESC(COCCC)N1C=2C(N=C(C1=O)N3CCN(CCO)CC3)=CN=C(C2)C=4C=CC(OC)=NC4
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Menniti FS, et al. Phosphodiesterase 5A inhibitors improve functional recovery after stroke in rats: optimized dosing regimen with implications for mechanism. J Pharmacol Exp Ther. 2009 Dec;331(3):842-50.?
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